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What Causes What
Lifestyle & environment

Resistance training

sessions / week

Progressive strength work. Moves body composition; T responses are acute and small at rest.

Training raises acute T and GH, improves insulin sensitivity, and changes how others read your body. Chronic basal T elevation in eugonadal adults is not a reliable training effect. The social signal may matter more than the ng/dL.

Also called strength training, weights.

Connected relationships

MECHANISM− DECREASES

Randomized trial · Moderate

Resistance training→Depression

Higher Resistance training decreases Depression.

Eight weeks of twice-weekly supervised resistance training lowered QIDS scores versus wait-list in 55 young adults. Depression was a secondary read of two anxiety-primary randomized trials.

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MECHANISM− DECREASES

Randomized trial · Moderate

Resistance training→Insulin resistance (HOMA-IR)

Higher Resistance training decreases Insulin resistance (HOMA-IR).

Waters 2022 randomized 160 older adults with obesity and found that resistance training during matched diet-induced weight loss of about 9 to 10 percent raised the OGTT insulin sensitivity index 39 percent; combination training raised it 86 percent.

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MECHANISM~ NON-LINEAR

Observational · Low

Resistance training→Testosterone

Higher Resistance training moves Testosterone in a non-linear way. Dose or timing can flip the sign.

Ahtiainen 2016: twelve months of resistance training left testosterone production and clearance unchanged in five men near 28 and eight men near 70; a 5×10RM session could raise serum T by slowing clearance.

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Sources