Rhodiola
mg/day extract
Rhodiola rosea root extract, often the SHR-5 preparation, at a few hundred milligrams a day. It is the plant extract, not sertraline.
Trials use a standardized rhizome extract for a few weeks in people with mild depression or stress complaints. Sertraline is a prescription drug used as a comparator in some files. A multivitamin that merely lists the plant is not the same exposure.
Also called Rhodiola rosea, SHR-5, golden root.
Connected relationships
Randomized trial · Contested
Rhodiola→Depression
Higher Rhodiola moves Depression only in some conditions. Read the mechanism.
Mao 2015 found that twelve weeks of Rhodiola rosea extract did not beat placebo on Hamilton change among 57 adults with mild-to-moderate major depression (-5.1 versus -4.6; groups P=0.79). Darbinyan 2008 reported that SHR-5 at 340 or 680 mg a day did move Hamilton scores versus placebo in 89 people.