Randomized trial · 2020

A registered replication study on oxytocin and trust

C. H. Declerck, C. Boone, L. Pauwels, B. Vogt, E. Fehr. Nature Human Behaviour · N=677.

A registered, high-powered double-blind replication, including the original minimal-social-contact condition, found no effect of oxytocin on trusting behavior there. Fehr is a coauthor of both the 2005 paper and this one.

Open source doi:10.1038/s41562-020-0878-x PMID 32514040

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The trust-hormone slogan is a 2005 RCT that did not survive its own authors' registered replication.

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What Causes What. “A registered replication study on oxytocin and trust.” https://whatcauseswhat.org/papers/p-declerck-2020 (atlas updated 2026-08-31).

https://whatcauseswhat.org/papers/p-declerck-2020