Randomized trial · 2005

Oxytocin increases trust in humans

M. Kosfeld, M. Heinrichs, P. J. Zak, U. Fischbacher, E. Fehr. Nature · N=58.

Intranasal oxytocin raised transfers in the trust game relative to placebo. The paper created the trust-hormone slogan. It is an RCT. It is not the last word.

Open source doi:10.1038/nature03701 PMID 15931222

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The trust-hormone slogan is a 2005 RCT that did not survive its own authors' registered replication.

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What Causes What. “Oxytocin increases trust in humans.” https://whatcauseswhat.org/papers/p-kosfeld-2005 (atlas updated 2026-08-31).

https://whatcauseswhat.org/papers/p-kosfeld-2005