Randomized trial · 1999

Impact of sleep debt on metabolic and endocrine function

K. Spiegel, R. Leproult, E. Van Cauter. The Lancet · N=11.

Sleep debt in young men raised evening cortisol and reduced glucose tolerance to a pre-diabetic range. Foundational endocrine-sleep trial.

Open source doi:10.1016/S0140-6736(99)01376-8 PMID 10560671

Edges that cite this paper

Sleep debt is an HPA intervention. It is also a HOMA-IR intervention.
You can buy a continuous glucose monitor or you can sleep. One of these has a trial behind it.
Alcohol is a sleep toxin with a sedative costume. It sits upstream of the sleep→T and sleep→cortisol arrows.

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What Causes What. “Impact of sleep debt on metabolic and endocrine function.” https://whatcauseswhat.org/papers/p-spiegel-1999 (atlas updated 2026-08-31).

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