Berberine
mg/day
A plant alkaloid, usually about 500 mg of berberine hydrochloride three times a day. Trials treat that salt as its own dose.
Trials often use about 1.0 to 1.5 g a day for three to five months in people with metabolic syndrome or type 2 diabetes. A multivitamin, a drink that adds hops, or a protocol paper with no result is not this exposure.
Also called berberine hydrochloride, Berberis.
Connected relationships
Randomized trial · Contested
Berberine→Insulin resistance (HOMA-IR)
Higher Berberine decreases Insulin resistance (HOMA-IR).
Perez-Rubio 2014 found that 500 mg of berberine three times a day for three months raised the Matsuda insulin-sensitivity index from 2.1 to 3.1 versus placebo in 24 people with metabolic syndrome. Zhang 2008 lowered glucose versus placebo in 116 people with type 2 diabetes; the clamp contrast missed.
Sources
- KG Pérez-Rubio et al. (2014). Effect of berberine administration on metabolic syndrome, insulin sensitivity, and insulin secretion.
- Y Zhang et al. (2008). Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine.
- VV Ruiz-Herrera et al. (2023). Pilot study on the efficacy and safety of berberine in people with metabolic syndrome and human immunodeficiency virus infection.