Wellbeing / quality of life
IWQOL-Lite-CT or SF-36 score
How a person rates daily function and life on a named scale such as IWQOL-Lite or SF-36. A depression score is a different object.
Obesity trials use the Impact of Weight on Quality of Life questionnaire and the SF-36 physical-functioning scale. Those scores track stairs, work, and self-consciousness about weight. They are not a diagnosis of depression and not a career score.
Also called quality of life, IWQOL, HRQOL, physical functioning.
Connected relationships
Randomized trial · Moderate
GLP-1 receptor agonist→Wellbeing / quality of life
Higher GLP-1 receptor agonist increases Wellbeing / quality of life.
In the STEP 1 trial of weekly semaglutide 2.4 mg, more people crossed a meaningful threshold on the Impact of Weight on Quality of Life physical-function scale than on placebo: 51.8 percent versus 28.3 percent (Rubino 2024). The same direction showed up on SF-36 physical functioning.
Sources
- D Rubino et al. (2024). Effect of semaglutide 2.4 mg on physical functioning and weight- and health-related quality of life in adults with overweight or obesity: Patient-reported outcomes from the STEP 1-4 trials.
- S Wharton et al. (2025). Oral Semaglutide at a Dose of 25 mg in Adults with Overweight or Obesity.